The Office of the School of Health and Natural Sciences has a rich history that dates back to the establishment of the College of Nursing at Saint Mary’s University. In June 1994, the Commission on Higher Education granted permits for SMU to offer the Bachelor of Science in Nursing (BSN) program.  The College of Nursing achieved government recognition in September 1998 to offer the four levels of the BSN program. The pioneer batch of nursing graduates obtained a 100% passing rate in the Nurse Licensure Examination, showcasing the excellent training provided by the college. The college also implemented programs related to Adolescent Reproductive Health and Violence Against Women, recognized by the United Nations Fund for Population Activities. The college expanded its programs and affiliations, with nursing students undergoing Related Learning Experience (RLE) activities in hospitals and communities. 

In addition to the local partner-hospitals, students were affiliated with prestigious hospitals in Manila, enhancing their learning experiences. In 2000, the College of Nursing was transformed into the College of Health Sciences, broadening its focus beyond nursing. The college introduced new programs, including Graduate in Midwifery, and later, Bachelor of Medical Laboratory Sciences and Bachelor of Science in Pharmacy. 

In the school year 2016-2017, as a result of a restructuring of the university’s schools, the Center for Natural Sciences merged with the School of Health Sciences. This led to the formation of the School of Health and Natural Sciences (SHaNS), under the leadership of various Academic Deans and Officers-in-charge. In terms of academic achievements, the school has produced top-notchers in licensure exams and has received recognition for its performance.